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E. STRATIKOS

Pleave visit his personal web page for more information

Dr. Efstratios Stratikos is an Associate Professor and the director of the Laboratory of Biochemistry at the department of Chemistry of the National and Kapodistrian University of Athens in Greece. He is also also an adjunct researcher and group leader at the National Centre for Scientific Research Demokritos. Dr. Stratikos studied chemistry at the University of Athens from 1989 to 1994 and received a PhD in Biochemistry from the University of Illinois in 1999. After postdoctoral training in Structural and Molecular biology at Harvard University, in 2005 he returned to Greece where he established the Protein Chemistry laboratory at the National Centre for Scientific Research Demokritos. He joined the Chemistry Department of the National and Kapodistrian University of Athens in 2020 as an Associate Professor of Biochemistry. His main research interests revolve around understanding complex biological systems at the molecular and atomic level. His laboratory studies the structure and function of protein biomolecules in an effort to understand their role, as well as the role of their disease-causing variants (such as rare mutations or single nucleotide polymorphisms), in the pathogenesis, predisposition and diagnosis of human disease. A main current focus in the lab is the study of biochemical pathways of the human immune system and in particular the pathway of antigen processing and presentation.

Google Scholar link here. Pubmed link here. Scopus link here.

Linkedin Profile here. ORCID profile here. ResearchGate here. 

Representative Publications (full list here)

Mechanisms of allosteric inhibition of Insulin- Regulated Aminopeptidase
Mpakali A, Barla I, Lu L, Ramesh KM, Thomaidis N, Stern LJ, Giastas P, and Stratikos E* 
J Mol Biol 2024, in press

Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
Temponeras I, Samiotaki M, Koumantou D, Nikopaschou M, Kuiper JJ, Panayotou G, Stratikos E*
Eur J Immunol 2023, May 3:e2350449. doi: 10.1002/eji.202350449

Discovery of Selective Nanomolar Inhibitors for Insulin- Regulated Aminopeptidase Based on α-Hydroxy-β-Amino Acid Derivatives of Bestatin
Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou S, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E* and Papakyriakou A*
J Med Chem, 2022, Jul 14. doi: 10.1021/acs.jmedchem.2c00904 

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 Spike Glycoprotein
Stamatakis G, Samiotaki M, Temponeras I, Panayotou G, Stratikos E.*
Journal of Biological Chemistry 2021, Oct 21:101329. doi: 10.1016/j.jbc.2021.101329.

Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism
Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ.
Nature Communications, 2021, Sep 6;12(1):5302. doi: 10.1038/s41467-021-25564-w.

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties
Hutchinson JP, Temponeras I, Kuiper J, Cortes A, Korczynska J, Kitchen S and Stratikos E*
Journal of Biological Chemistry 2021, Jan-Jun 2021;296:100443. doi: 10.1016/j.jbc.2021.100443.

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation. (read here)
Liddle J, Hutchinson JP, Kitchen S, Rowland P, Neu M, Cecconie T, Holmes DS, Jones EJ, Korczynska J, Koumantou D, Lea J, Nickels LA, Pemberton M, Phillipou A, Schneck JL, Sheehan H, Tinworth CP, Uings I, Wojno-Picon J, Young RJ, Stratikos E*.
J Med Chem. 2020 Feb 28. doi: 10.1021/acs.jmedchem.9b02123.

Mechanism for antigenic peptide selection by ER aminopeptidase 1.
Giastas P#, Mpakali A#, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D and Stratikos E*.
PNAS 2019, December 16, 2019 https://doi.org/10.1073/pnas.1912070116.

Editing the immunopeptidome of melanoma cells using a potent inhibitor of Endoplasmic Reticulum aminopeptidase. (read paper here)
Koumantou D, Barnea E, Martin-Esteban A, Maben A, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A and Stratikos E*
Cancer Immunol Immunother 2019, Jun 20. doi: 10.1007/s00262-019-02358-0.

A rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses.
Zervoudi E, Saridakis E, Birtley JR, Seregin S., Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D* and Stratikos E*.
Proc Natl Acad Sci USA, 2013 Dec 3;110(49):19890-5.

A common SNP in ER aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM and Stratikos E*
J Immunol. 2012, Sep 1;189(5):2383-92.

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.
Kim S, Lee S, Shin J, Kim Y, Evnouchidou I, Kim D, Kim YK, Kim YE, Ahn JH, Riddell SR, Stratikos E, Kim VN, Ahn K.
Nat Immunol. 2011 Sep 4. doi: 10.1038/ni.2097.
 

CURRICULUM VITAE
  • 2021-present: Director, Laboratory of Biochemistry, Department of Chemistry, National and Kapodistrian University of Athens
  • 2020-present: Associate Professor, Department of Chemistry, National and Kapodistrian University of Athens, Greece
  • 2020-present: Adjunct Researcher, National Center for Scientific Research "Demokritos", Athens, Greece
  • 2014-2020: Research director, National Center for Scientific Research “Demokritos”, Athens, Greece
  • 2015-2017: Visiting Professor, Department of Chemistry, University of Athens, Greece
  • 2009-2014: Senior Researcher, National Center for Scientific Research “Demokritos”, Athens, Greece
  • 2005-2008: Researcher, National Center for Scientific Research “Demokritos”, Athens, Greece
  • 2003-2004: Postdoctoral researcher, Department of Cell Biology, Harvard Medical School, Boston, MA
  • 1999-2003: Postdoctoral researcher, Structural Biology Laboratory, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
  • 1994-1999: PhD in Biochemistry, Department of Biochemistry and Molecular Biology,University of Illinois at Chicago, Chicago, IL, USA,Advisor: Dr. Peter G.W. Gettins
  • 1989-1994: B.S. Degree in Chemistry, University of Athens, Athens, Greece.
Contact Information:

National and Kapodistrian University of Athens
Department of Chemistry
Zografou 157 84, Greece
Office: Ground floor, Office 19
Tel: +30-210-7274471
Fax: +30-210-7274476
Email: estratikos [at] chem.uoa.gr

 

PERSONNEL: