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Dr. Evangelia Emmanouilidou is an Assistant Professor of Biochemistry at  the department of Chemistry of the National and Kapodistrian University of Athens in Greece  and also an adjunct researcher at the Biomedical Research Foundation of the Academy of Athens. Dr. Emmanouilidou graduated with a degree in Chemistry from the University of Athens in 1998, obtained a Master’s degree in Biochemistry from the University of Bristol in 1999 and a PhD degree in Chemistry from the University of Athens in 2003. She worked as a postdoctoral researcher at the Biomedical Research Foundation of the Academy of Athens from 2004 to 2018 and joined the Chemistry Department of the National and Kapodistrian University of Athens in 2018 as an Assistant Professor of Biochemistry. The major focus of her research work involves the investigation of the molecular mechanisms of protein secretion and degradation that are of particular importance in neurodegenerative disorders. More specifically, Dr. Emmanouilidou’s research focuses on  α-synuclein, a small, pre-synaptic neuronal protein, which plays a central role in the pathobiology of Parkinson’s Disease (PD) and other related neurodegenerative conditions collectively called synucleinopathies.

Representative Publications

Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
Samantha Sykioti V, Karampetsou M, Chalatsa I, Polissidis A, Michael IP, Pagaki-Skaliora M, Nagy A, Emmanouilidou E, Sotiropoulou G, Vekrelli S K.
J Neurochem. 2021 Jun;157(6):2024-2038. doi: 10.1111/jnc.15199. Epub 2020 Oct 19.
PMID: 32974895

Changes in the cellular fatty acid profile drive the proteasomal degradation of α-synuclein and enhance neuronal survival.
Xylaki M, Boumpoureka I, Kokotou MG, Marras T, Papadimitriou G, Kloukina I, Magrioti V, Kokotos G, Vekrellis K, Emmanouilidou E.
FASEB J. 2020 Nov;34(11):15123-15145. doi: 10.1096/fj.202001344R. Epub 2020 Sep 15.
PMID: 32931072

GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum.
Emmanouilidou E, Minakaki G, Keramioti MV, Xylaki M, Balafas E, Chrysanthou-Piterou M, Kloukina I, Vekrellis K.
Brain. 2016 Mar;139(Pt 3):871-90. doi: 10.1093/brain/awv403. Epub 2016 Feb 8.
PMID: 26912647

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome.
Emmanouilidou E, Stefanis L, Vekrellis K.
Neurobiol Aging. 2010 Jun;31(6):953-68. doi: 10.1016/j.neurobiolaging.2008.07.008. Epub 2008 Aug 20.
PMID: 18715677

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.
Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L, Vekrellis K.
J Neurosci. 2010 May 19;30(20):6838-51. doi: 10.1523/JNEUROSCI.5699-09.2010.
PMID: 20484626 Free PMC article.

Contact information:

Dr. Evangelia Emmanouilidou
National and Kapodistrian University of Athens
Department of Chemistry
Zografou 157 84, Greece
Office: Ground floor, Office 18
Tel: +30-210-7274472
Fax: +30-210-7274476
email: eemman [at]